Skip to main content

Upstream – Cell culture

Automation of Upstream Bioproduction Processes Using Single-Use Systems

Discover more

Automation of Upstream Bioproduction Processes Using Single-Use Systems

Cilyx expertise

In the pharmaceutical industry, the automation of bioprocesses has become essential to improving the efficiency and reproducibility of cell cultures and microorganisms. Our cutting-edge bioprocess automation solution offers optimized management of the upstream phase of bioproduction, ensuring reliable results and strict compliance with regulatory standards.

Our approach

The automation of bioproduction using cell stacks and cell factories is a valuable aid that allows biopharmaceutical production units to achieve both quantitative and qualitative objectives. The advantages in terms of traceability and repeatability of filling, emptying, rinsing, shaking, and harvesting cycles make these solutions invaluable.

Our solutions are fully customizable and can be configured to meet your requirements.

Contact us

SOLUTION DESCRIPTION

The automation of bioproduction frequently requires the use of intermediate processes for the development of cell cultures or microorganisms. These cultures serve as the basis for the production of Active Pharmaceutical Ingredients (APIs), such as viruses, monoclonal antibodies, exosomes, or other complex biological products.

Cilyx stands out for its expertise in bioprocess automation, particularly in the upstream phase of bioproduction using Single Use Systems, such as bioreactors and multi-layered cell culture platforms (like Cell Factory™ or Cell Stacks™).

Our solution enables precise and continuous monitoring of critical production parameters, including pH, temperature, dissolved oxygen concentration, agitation factors, and cell density.

Through this automation, cell culture processes become more homogeneous, thereby reducing inter-batch variations and significantly increasing production yields. Simultaneously, the automated generation of batch records and audit trails enhances production traceability, ensuring compliance with Good Manufacturing Practices (GMP) and facilitating internal and external audits.

CONCLUSION

Our bioprocess automation solution for the pharma and biotech sectors represents a significant advancement in the management of cell and microbial cultures. By choosing Cilyx, you benefit from technology that not only improves the efficiency and quality of your production but also guarantees strict compliance with the highest industry standards.

Advantages

  • <b>Increased Homogeneity and Yield</b>: Automation ensures reproducible culture conditions, improving the quality of produced batches and reducing rejection rates.
  • <b>Enhanced Traceability and Compliance</b>: The automated generation of batch records and audit trails ensures impeccable traceability and compliance with regulations, simplifying audit processes.
  • <b>Real-Time Data Optimization</b>: Integration with LIMS (Laboratory Information Management Systems) and MES (Manufacturing Execution Systems) allows for optimized data management, real-time monitoring, and proactive response to deviations, promoting continuous process improvement.
  • Simultaneous handling of up to 6 CF40 racks
  • Fluid transfers (suspended cells, media, etc.) regulated by peristaltic pumps and pinch valves

Do you need help?

See our frequently asked questions to find the answer, or contact us.

See all FAQ

Ask for an analysis of your needs

Discover how our solutions can be tailored to your situation. Contact our experts to analyse your process and define the most relevant approach.

Contact our experts