Cell & microbial culture automation
Automation of Upstream Bioproduction Processes Using Single-Use Systems
Automation of Upstream Bioproduction Processes Using Single-Use Systems
Cilyx expertise
In the pharmaceutical industry, the automation of bioprocesses has become essential to improving the efficiency and reproducibility of cell cultures and microorganisms. Our cutting-edge bioprocess automation solution offers optimized management of the upstream phase of bioproduction, ensuring reliable results and strict compliance with regulatory standards.
Our approach
The automation of bioproduction using cell stacks and cell factories is a valuable aid that allows biopharmaceutical production units to achieve both quantitative and qualitative objectives. The advantages in terms of traceability and repeatability of filling, emptying, rinsing, shaking, and harvesting cycles make these solutions invaluable.
Our solutions are fully customizable and can be configured to meet your requirements.
SOLUTION DESCRIPTION
The automation of bioproduction frequently requires the use of intermediate processes for the development of cell cultures or microorganisms. These cultures serve as the basis for the production of Active Pharmaceutical Ingredients (APIs), such as viruses, monoclonal antibodies, exosomes, or other complex biological products.
Cilyx stands out for its expertise in bioprocess automation, particularly in the upstream phase of bioproduction using Single Use Systems, such as bioreactors and multi-layered cell culture platforms (like Cell Factory™ or Cell Stacks™).
Our solution enables precise and continuous monitoring of critical production parameters, including pH, temperature, dissolved oxygen concentration, agitation factors, and cell density.
Through this automation, cell culture processes become more homogeneous, thereby reducing inter-batch variations and significantly increasing production yields. Simultaneously, the automated generation of batch records and audit trails enhances production traceability, ensuring compliance with Good Manufacturing Practices (GMP) and facilitating internal and external audits.
CONCLUSION
Our bioprocess automation solution for the pharma and biotech sectors represents a significant advancement in the management of cell and microbial cultures. By choosing Cilyx, you benefit from technology that not only improves the efficiency and quality of your production but also guarantees strict compliance with the highest industry standards.
Advantages
- <b>Increased Homogeneity and Yield</b>: Automation ensures reproducible culture conditions, improving the quality of produced batches and reducing rejection rates.
- <b>Enhanced Traceability and Compliance</b>: The automated generation of batch records and audit trails ensures impeccable traceability and compliance with regulations, simplifying audit processes.
- <b>Real-Time Data Optimization</b>: Integration with LIMS (Laboratory Information Management Systems) and MES (Manufacturing Execution Systems) allows for optimized data management, real-time monitoring, and proactive response to deviations, promoting continuous process improvement.
- Simultaneous handling of up to 6 CF40 racks
- Fluid transfers (suspended cells, media, etc.) regulated by peristaltic pumps and pinch valves
Do you need help?
See our frequently asked questions to find the answer, or contact us.
Artificial intelligence (AI) can offer several significant advantages in a production workshop. Here are some of the key benefits that AI can bring to a manufacturing environment:
- Process optimization :
- AI can analyze large amounts of data in real time to identify patterns, trends and inefficiencies in production processes.
- It can help optimize production parameters to improve efficiency and reduce costs.
- Predictive maintenance :
- By using sensors and monitoring systems, AI can predict potential equipment failures before they occur.
- This enables proactive maintenance planning, reducing unplanned downtime.
- Quality control :
- AI systems, including computer vision, can inspect and evaluate product quality in real time.
- This helps to minimize defects and maintain high quality standards.
- Adaptability and flexibility :
- AI can help automate production processes, allowing greater adaptability to changes in demand and more flexible production.
- Data driven decision making :
- AI can quickly process complex data to support decision-making.
- Predictive analytics and machine learning models can help optimize operational decisions.
- Reducing labour costs :
- AI-based automation can replace some manual tasks, reducing labor costs and allowing workers to focus on more complex tasks.
- Improving safety
- AI systems can monitor working conditions and prevent hazardous situations, helping to improve worker safety.
- Continuous innovation:
- AI encourages continuous innovation by enabling companies to explore new approaches and develop smarter solutions for production challenges.
However, it is important to note that successful implementation of AI in a production shop requires careful planning, adequate training of staff and effective integration with existing processes. Companies must also consider the ethical and social implications of automating and using AI in the workplace.
Managing a robotics project, especially when it’s the first time for a company, can be complex but crucial to ensure implementation success. Here are some tips to help manage such a project:
- Needs Assessment :
- Clearly identify the tasks or processes that the robot must perform.
- Analyze the expected benefits in terms of productivity, quality and profitability.
- training and awareness :
- Train staff on the use of the robot and explain the benefits of this technology.
- Involve the teams that will be directly affected by the robot in the process.
- Selecting the right robot:
- Choose a robot adapted to your company’s specific needs in terms of payload, speed, precision, etc.
- Also consider the safety and compatibility aspects with other equipment.
- Development of a detailed project plan :
- Identify the project milestones, timelines and responsibilities of each team member.
- Allow room for contingencies.
- Resource management:
- Allocate the necessary resources, including staff, time and budget.
- Make sure the team has the technical skills to manage and maintain the robot.
- Testing and validation:
- Perform thorough testing before commissioning to identify and correct any problems.
- Involve end users in the validation process to gather their feedback.
- Safety :
- Prioritize the safety of staff by implementing adequate security measures.
- Comply with current security standards and ensure that all personnel are trained in security protocols.
- Continuous communication :
- Communicate regularly with stakeholders throughout the project.
- Be transparent about progress, challenges and solutions.
- Maintenance and support :
- Develop a preventive maintenance plan to ensure that the robot is running smoothly.
- Make sure you have access to technical support in case of problems.
- Post-implementation evaluation:
- Evaluate the results after commissioning the robot.
- Identify lessons learned and use this information to improve future projects.
By following these tips, you will increase your chances of success in implementing your first robotics project. Cilyx can assist you in this process.
The combination of artificial vision and adaptive robotics represents real progress in various fields and offers several advantages. Here are some key aspects of these technologies and the benefits they bring:
- Flexibility and Adaptability :
- Adaptive robotics allow robots to adjust to changing environments and interact flexibly with their surroundings.
- Combined with artificial vision, robotics can recognize and react to unexpected objects and situations, improving the adaptability of automated systems.
- Reduction of Programming Time :
- Artificial vision can be used to teach robots specific tasks by simply showing visual examples rather than resorting to complex manual programming.
- This reduces programming time and enables faster commissioning of robotic systems.
- Improvement of Precision and Quality :
- Artificial vision allows advanced visual perception, allowing robots to perform tasks with high precision.
- This improves the quality of automated operations, especially in areas such as assembly, welding and inspection.
- Human-Robot interaction more Intuitive :
- By using artificial vision, robots can detect and react to human movements and actions, facilitating more natural interaction with human operators.
- This paves the way for safer and more efficient collaborative work environments.
- Adaptation to Product Variations:
- The combination of vision and adaptive robotics allows systems to adapt to product variations without requiring extensive reprogramming.
- This is especially beneficial in manufacturing environments where frequent product changes are common.
- Predictive maintenance :
- Vision systems can be used to monitor the condition of components and equipment.
- Adaptive robotics can respond to this data by anticipating maintenance needs, helping to reduce unplanned downtime.
- Reduction of Labour Costs:
- By automating complex tasks with advanced vision and adaptive robotics, companies can reduce labor costs and improve operational efficiency.
While these advances are promising, it is essential to consider potential challenges such as safety, ethics, staff training and change management when adopting these technologies. Successful implementation requires thorough planning and careful integration into existing processes. Cilyx can assist you in this process.
Ask for an analysis of your needs
Discover how our solutions can be tailored to your situation. Contact our experts to analyse your process and define the most relevant approach.